IB Biology SL D2.1 Cell and nuclear division Questions

Practise IB Biology SL D2.1 by identifying mitosis stages, explaining cytokinesis and interpreting cell-division evidence.

75 questions in this syllabus scope, with question parts counted together.

Syllabus
First assessment 2025
Course
Biology SL
Level
SL

Exam analysis

SL · 2010–2025
Papers with this topic62 / 141in the analysed sample
Latest appearanceNovember 2025
Tagged question parts88
Paper types5

Most tested objectives

  1. D2.1.10—Down syndrome16 papers
  2. D2.1.9—Meiosis as reduction division15 papers
  3. D2.1.8—Identification of mitosis phases14 papers
  4. D2.1.7—Phases of mitosis12 papers
  5. D2.1.1—Generation of new cells7 papers

Common question formats

  • Definition or recall
  • Process explanation
  • Diagram interpretation
  • Calculation
  • Data analysis
  • Comparison

Recent exam appearances

November 2025Paper 1B SL · TZ3Q4(a), 4(b)[ 3 ]
November 2025Paper 1B SL · TZ1Q4(a)[ 2 ]
November 2025Paper 1A SL · TZ3Q12[ 1 ]

141 papers analysed · Tagging incomplete

Exam points

  • link mitosis to new-cell production for growth, tissue replacement, repair or asexual reproduction
  • describe animal-cell cleavage-furrow cytokinesis and identify unequal division in yeast budding
  • compare mitosis and meiosis by cell number, chromosome number and genetic similarity
  • link pre-division DNA replication to sister chromatids and higher DNA quantity at G2 than G1
  • identify chromosome events shared by mitosis and meiosis, including sister-chromatid separation
  • sequence mitotic phases from chromosome/spindle events and identify them in diagrams or micrographs
  • explain how mitosis produces two genetically identical nuclei with the expected chromosome number
  • trace DNA replication through meiosis I/II, homologous then sister-chromatid separation to haploid nuclei
  • explain non-disjunction and interpret chromosome counts or karyotypes for trisomy 21
  • explain crossing over and random homologous-chromosome assortment as sources of genetic variation

Exam points

  • State that mitosis divides one nucleus to produce two genetically identical nuclei or cells.
  • Explain how chromosome replication and sister-chromatid separation pass the same hereditary information to daughter cells.
  • Identify mitosis as a process that contributes to growth in a multicellular organism.

Question 1

[Maximum number: 3]

Hereditary information is stored in nucleic acids and passed on to offspring.

Outline how mitosis allows for the same hereditary information to be passed on to new cells.

Exam points

  • Explain animal-cell cytokinesis: an actin–myosin contractile ring pulls the plasma membrane inward to split the cytoplasm.

Question 1

[Maximum number: 2]

Both the genome and the environment of an organism affect its growth and development. Variation between individuals of a species can be continuous or discrete (discontinuous). Mitosis produces identical cells for growth and meiosis allows for variation.

The micrographs show onion and whitefish cells in mitosis.

Figure for Question 1 — IB Biology SL

The process of cytokinesis is occurring in the whitefish embryo cells. Explain how cytokinesis occurs in this animal cell.

Exam points

  • Identify yeast budding as unequal cytokinesis, in which daughter cells receive different amounts of cytoplasm.

Question 1

[Maximum number: 1]

Daughter cells usually receive equal amounts of cytoplasm as parent cells undergo cytokinesis. Which of the following is an exception?

A

Asexual reproduction by budding in yeast

B

Bacterial cell division

C

Cloning of lymphocytes during an immune response

D

Formation of a zygote during fertilization

Exam points

  • Identify mitosis as the process used for growth, tissue repair and asexual reproduction.
  • Explain that meiosis produces haploid gametes and increases genetic diversity; fertilisation restores diploidy.
  • Compare mitosis and meiosis by daughter-cell number, chromosome number and genetic similarity.

Question 1

[Maximum number: 2]

The image shows a cell in the anther of a lily (Lilium sp.) plant during the first division of meiosis.

Figure for Question 1 — IB Biology SL

Outline the reason for diploid organisms producing haploid cells by meiosis.

Exam points

  • Recognize that paired sister chromatids visible during meiosis result from DNA replication before meiosis.
  • Distinguish G1 and G2 DNA quantity: DNA quantity doubles by G2.
  • Calculate chromatid number after replication from diploid chromosome number; a 2n=16 late-prophase cell has 32 chromatids.

Question 1

[Maximum number: 1]

Which is a characteristic of the pairs of sister chromatids that are visible during meiosis?

A

They result from the replication of DNA before meiosis.

B

They are only present in meiosis I.

C

They split apart during metaphase I in meiosis.

D

They are only present in meiosis II.

Exam points

  • Identify sister-chromatid separation as an event common to mitosis and meiosis.
  • Identify anaphase microtubule movement of chromatids as a shared feature of both divisions.

Question 1

[Maximum number: 1]

What occurs in cell division during both mitosis and meiosis?

A

Condensation of DNA by supercoiling in telophase

B

Movement of microtubules to move chromatids in anaphase

C

Pairing of homologous chromosomes in prophase

D

Crossing over between chromosomes in metaphase

Exam points

  • Sequence prophase, metaphase, anaphase and telophase, matching each phase to its chromosome events.
  • Explain how sister chromatids separate and move to opposite poles during anaphase.
  • Calculate chromosome number during anaphase from the diploid number; a cell with 2n=20 has 40 chromosomes during anaphase.

Question 1

[Maximum number: 1]

The micrograph shows cells dividing by mitosis in the root tip of an onion (Allium cepa).

Figure for Question 1 — IB Biology SL

Which change would take place in cell Y if mitosis was allowed to continue?

A

Splitting of centromeres

B

Formation of spindle fibres

C

Supercoiling of chromosomes

D

Separation of homologous pairs

Exam points

  • Identify a mitotic phase from chromosome position, condensation or nuclear-membrane cues in a diagram or micrograph.
  • Distinguish the order or early/intermediate timing of mitotic phases from visible cell events.

Question 1

[Maximum number: 1]

The micrograph shows onion (Allium cepa) root tip cells dividing by mitosis.

Figure for Question 1 — IB Biology SL

In which phase is cell Z ?

A

Interphase

B

Prophase

C

Metaphase

D

Anaphase

Exam points

  • Explain how meiosis halves chromosome number: homologous chromosomes separate in meiosis I, then sister chromatids separate in meiosis II.
  • Determine the chromosome number or DNA amount in haploid gametes, or the number and ploidy of cells after meiosis I or II.

Question 1

[Maximum number: 1]

What occurs during the first division of meiosis?

A

Replication of DNA

B

Separation of chromatids

C

Halving of the chromosome number

D

Production of two identical cells

Exam points

  • Explain how homologues failing to separate in meiosis I, or sister chromatids in meiosis II, produces gametes with abnormal chromosome numbers.
  • Relate non-disjunction of chromosome 21 to trisomy 21 and Down syndrome after fertilization.
  • Explain the link between maternal age and the increased risk of chromosome-21 non-disjunction.

Question 1

[Maximum number: 1]

There is no evidence that rates of non-disjunction in meiosis increase as the age of the father increases from 30 to 45, yet the frequency of Down syndrome in offspring increases. What could explain this?

A

Down syndrome is not caused by non-disjunction.

B

Meiosis rates decrease in males between the ages of 30 and 45 .

C

Down syndrome is sex-linked, so non-disjunction can only take place in the mother.

D

Rates of non-disjunction increase as the age of the mother increases, and parents of a child tend to be similar in age.

Exam points

  • Describe how crossing over exchanges DNA between non-sister chromatids at prophase I chiasmata.
  • Explain how crossing over and random orientation of homologous chromosomes create new allele combinations.

Question 1

[Maximum number: 1]

During which stage of meiosis does crossing over usually occur?

A

Prophase I

B

Metaphase I

C

Prophase II

D

Metaphase II

Question 1

[Maximum number: 3]

Both the genome and the environment of an organism affect its growth and development. Variation between individuals of a species can be continuous or discrete (discontinuous). Mitosis produces identical cells for growth and meiosis allows for variation.

The micrographs show onion and whitefish cells in mitosis.

Figure for Question 1 — IB Biology SL

Question (a)

(a)

Identify the phase of mitosis labelled X .

[ 1 ]

Question (b)

(b)

The process of cytokinesis is occurring in the whitefish embryo cells. Explain how cytokinesis occurs in this animal cell.

[ 2 ]
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