IB Biology HL A2.3 Viruses [HL only] Questions

Practise IB Biology HL A2.3 across virus structure, replication cycles and rapid evolution, using route-specific questions and mark-scheme evidence.

11 questions in this syllabus scope, with question parts counted together.

Syllabus
First assessment 2025
Course
Biology HL
Level
HL

Exam analysis

HL · 2010–2025
Papers with this topic11 / 117in the analysed sample
Latest appearanceNovember 2025
Tagged question parts13
Paper types5

Most tested objectives

  1. A2.3.1 (HL)—Common structural features5 papers
  2. A2.3.2 (HL)—Diversity of virus structure3 papers
  3. A2.3.6 (HL)—Rapid evolution in viruses2 papers
  4. A2.3.3 (HL)—Lytic cycle1 paper
  5. A2.3.4 (HL)—Lysogenic cycle1 paper

Common question formats

  • Definition or recall
  • Diagram interpretation
  • Structured response
  • Comparison
  • Process explanation
  • Extended response
  • Data analysis

Recent exam appearances

November 2025Paper 2 HL · TZ3Q2(b)[ 2 ]
November 2025Paper 2 HL · TZ1Q7(b)[ 7 ]
November 2025Paper 1B HL · TZ3Q1(d)[ 3 ]

117 papers analysed · Tagging incomplete

Exam points

  • identify common viral structure using a DNA or RNA genome, protein capsid, absent cytoplasm and absent ribosomes
  • explain obligate parasitism and non-living classification from host dependence, absent metabolism and cellular reproduction
  • identify capsids and visible viral components in labelled images or electron micrographs
  • compare viral genomes, capsid architectures and envelope status using lambda phage, HIV, TMV or coronavirus examples
  • justify vaccine strategies from viral DNA or RNA, capsid proteins and attenuation or inactivation
  • compare lambda lytic and lysogenic cycles using DNA injection or integration, host machinery, assembly and lysis
  • explain prophage replication through binary fission and stress-induced excision into the lytic cycle
  • explain rapid viral evolution through mutation without proofreading, recombination or horizontal gene transfer and short generation times
  • use viral variation, natural selection and immune escape to explain antigenic change and effects on vaccines or secondary responses

Exam points

  • Describe viruses as non-cellular obligate parasites with a fixed small size.
  • State that a viral genome consists of either DNA or RNA surrounded by a protein capsid.
  • State that viruses lack cytoplasm, ribosomes and most metabolic enzymes.

Question 1

[Maximum number: 1]

Which feature is common to all viruses?

A

Has a capsid

B

Contains RNA

C

Contains cytoplasm

D

Enveloped in host cell membrane

Exam points

  • Describe viral genomes as DNA or RNA that may be single- or double-stranded, linear, circular or segmented.
  • Describe viral capsids as helical, polyhedral, conical or complex, and distinguish enveloped from non-enveloped viruses.
  • Use TMV, HIV, coronavirus and lambda phage as examples of viral structural diversity.

Question 1

[Maximum number: 2]

Outline how the nucleic acids used as the genetic material in viruses may vary.

Exam points

  • Describe lambda phage attaching to E. coli and injecting double-stranded DNA.
  • Explain that viral DNA remains separate, host DNA is degraded and host machinery produces viral parts.
  • Describe assembly of new phages and their release by lysis of the host cell.

Question 1

[Maximum number: 3]

The micrograph is an image of human cheek cells viewed with a light microscope.

Figure for Question 1 — IB Biology HL

Viruses depend on living cells to reproduce. Compare and contrast the lysogenic and lytic cycles of the bacteriophage lambda.

Exam points

  • Describe lambda phage DNA integrating into the E. coli chromosome as a prophage.
  • Explain how prophage DNA replicates with the host genome during binary fission.
  • Explain how stress can induce prophage excision and entry into the lytic cycle.

Question 1

[Maximum number: 3]

The diagram shows the structure of a bacteriophage lambda virus.

Figure for Question 1 — IB Biology HL

Explain how the bacteriophage lambda reproduces in the lysogenic cycle.

No public sample questions are available for this syllabus point yet.

Exam points

  • Explain how mutation, recombination, large population size and short life cycles drive rapid viral evolution.
  • Explain why RNA viruses often mutate rapidly when replication lacks proofreading, including errors by HIV reverse transcriptase.
  • Relate influenza antigenic drift and shift to their effects on vaccines and treatments.

Question 1

[Maximum number: 1]

A secondary immune response occurs when an antigen is encountered on a second occasion, due to exposure to a pathogen that previously caused infection. Which property of some viruses explains the lack of a secondary immune response?

A

Viruses fail to induce a primary response.

B

Viruses can have a high mutation rate.

C

B cells do not interact with viruses.

D

Antibodies cannot interact with viruses.