IB Biology HL C3.1 Integration of body systems Questions

Practise IB Biology HL C3.1 by tracing reflex pathways and explaining feedback control, endocrine signals, ventilation and plant responses.

177 questions in this syllabus scope, with question parts counted together.

Syllabus
First assessment 2025
Course
Biology HL
Level
HL

Exam analysis

HL · 2010–2025
Papers with this topic63 / 117in the analysed sample
Latest appearanceNovember 2025
Tagged question parts113
Paper types5

Most tested objectives

  1. C3.1.1—System integration11 papers
  2. C3.1.13—Hypothalamus and pituitary control11 papers
  3. C3.1.18 (HL)—Positive phototropism11 papers
  4. C3.1.15—Ventilation rate feedback control10 papers
  5. C3.1.4—Brain as information integration organ8 papers

Common question formats

  • Structured response
  • Definition or recall
  • Diagram interpretation
  • Process explanation
  • Extended response
  • Calculation
  • Experimental design
  • Comparison
  • Data analysis
  • Graph interpretation

Recent exam appearances

November 2025Paper 2 HL · TZ3Q4(b)(ii)[ 2 ]
November 2025Paper 1A HL · TZ3Q27, 28[ 2 ]
November 2025Paper 1A HL · TZ1Q26, 27[ 2 ]

117 papers analysed · Tagging incomplete

Exam points

  • Explain emergent system properties as interacting components are organized from cells through tissues and organs.
  • Identify brain-region functions and use lesion, fMRI or movement evidence to explain integrated responses.
  • Trace a rapid withdrawal reflex from sensory input to motor output and skeletal-muscle response.
  • Explain darkness-triggered melatonin secretion and its role in circadian sleep timing.
  • Explain epinephrine effects on heart rate, ventilation and respiratory-fuel availability during stress.
  • Explain hypothalamic-pituitary endocrine control and interpret hormone-response data such as leptin's effect on appetite.
  • Explain medullary feedback control of heart rate and ventilation in response to blood-pressure and CO₂/pH signals.
  • Explain how peristalsis moves food through the intestine from the stomach toward the large intestine.
  • Explain positive shoot phototropism through auxin transport, shaded-side redistribution and acid-growth-driven elongation.
  • Identify auxin and cytokinin as phytohormones and relate their roles to plant growth and gene expression.
  • Explain ethylene-driven fruit ripening as positive feedback affecting nearby fruit.

Exam points

  • Explain emergent properties as system-level features that arise through interactions among components and are not present in individual parts.
  • Use biofilm evidence to explain how features such as EPS, quorum sensing, high cell density or slow growth help communities survive and resist treatment.

Question 1

[Maximum number: 1]

Though a single nerve cell does not think, millions of them organized as a brain result in thinking. What kind of property does thinking represent?

A

Anatomical

B

Adaptive

C

Extracellular

D

Emergent

Exam points

  • Trace nutrient-rich blood from the digestive tract through the hepatic portal vein and liver sinusoids to the hepatic vein, and explain how the liver stores or regulates the nutrients it receives.

Question 1

[Maximum number: 3]

Stomach ulcers are often caused by Helicobacter pylori infection. These bacteria attach to the cells of the stomach wall using flagella. They secrete ammonia that neutralizes the acid in the immediate vicinity of the bacterial cells.

Figure for Question 1 — IB Biology HL

The liver is a large, complex organ with many metabolic functions. Outline the role of the liver in regulating the levels of nutrients in the blood.

Exam points

  • Compare methods such as lesion studies and fMRI for linking brain regions to functions, and explain how fMRI uses blood-flow changes to reveal active areas.
  • Identify the roles of named brain regions: the cerebellum coordinates movement and balance, the medulla controls involuntary responses, and the hypothalamus regulates homeostasis and hormone release.

Question 1

[Maximum number: 1]

The diagram is a view of the human brain as seen from the left side.

Figure for Question 1 — IB Biology HL

On the diagram, label the cerebellum.

The graph shows the mean cerebellum volume from MRI scans in eight primate species arranged in order of increasing body mass.

Figure for Question 1 — IB Biology HL

Question 1

[Maximum number: 1]

The spinal cord is involved in the coordination of involuntary actions such as the pain reflex.

Where are synapses between sensory neurons and interneurons found?

Figure for Question 1 — IB Biology HL

Exam points

  • Explain how sensory receptors detect visual or auditory stimuli and how nerve impulses travel through the optic or auditory nerve to the brain.

Question 1

[Maximum number: 3]

The image shows the anatomy of the human ear.

Figure for Question 1 — IB Biology HL

Explain how sound waves arriving at the inner ear are processed.

Question 1

[Maximum number: 1]

What is the main role of nerves in human movement?

A

To cause muscles to stretch

B

To move joints

C

To transport pain signals that indicate muscle injuries

D

To stimulate muscle contraction

No public sample questions are available for this syllabus point yet.

Exam points

  • Trace a pain-reflex arc in order from the receptor through sensory, relay and motor neurons to a skeletal-muscle effector.
  • Identify skeletal muscle as the effector in a pain-reflex arc.

Question 1

[Maximum number: 1]

Which is the effector in a pain reflex arc?

A

Skeletal muscle

B

Sensory nerve ending

C

Pituitary gland

D

Grey matter of spinal cord

Exam points

  • Identify the cerebellum as the brain region responsible for balance and coordinated movement.

Question 1

[Maximum number: 1]

The drawing shows a vertical section through the brain.

Figure for Question 1 — IB Biology HL

State a function of the cerebellum.

Exam points

  • Connect pineal melatonin secretion in darkness with circadian rhythms and the timing of sleep.
  • Apply melatonin’s role in circadian timing to explain sleep difficulty after jet lag or choose a suitable time to take melatonin.

Question 1

[Maximum number: 1]

Jetlag occurs when the circadian rhythm of a person changing time zones is disrupted. For what reason might they have difficulty sleeping after sunset?

A

The hypothalamus is secreting too much melanin.

B

The pineal gland is not secreting sufficient melatonin.

C

The lack of sunlight inhibits the production of vitamin D.

D

The pituitary gland is secreting too much oxytocin.

Exam points

  • Explain how epinephrine increases sinoatrial-node signalling and heart rate during anticipated activity, supporting blood, oxygen and glucose delivery to working muscles.

Question 1

[Maximum number: 1]

An individual was presented with a stimulus resulting in the release of epinephrine. What was the most likely nature of the stimulus?

A

Sunset and the onset of darkness

B

An image of a close friend

C

The intake of glucose

D

A coach shouting to begin physical activity

Exam points

  • Relate hypothalamic functions such as appetite regulation and homeostasis to control of pituitary hormone secretion.
  • Identify the pituitary as an endocrine gland and describe hormone control of reproductive or mammary functions.

Question 1

[Maximum number: 2]

The hypothalamus is a region of the brain with a wide range of regulatory functions.

Figure for Question 1 — IB Biology HL

Outline two regulatory functions of the hypothalamus.
1.
2.

Exam points

  • Explain how medullary sympathetic and parasympathetic signals adjust sinoatrial-node activity to increase or decrease heart rate.

Question 1

[Maximum number: 7]

Explain the control mechanism of the heart rate.

Exam points

  • Explain how increased blood CO₂ or lower pH is detected by chemoreceptors and signalled to the medulla.
  • Trace how medullary signals alter diaphragm and intercostal muscle activity to change ventilation and remove CO₂.

Question 1

[Maximum number: 2]

The effects of altitude on athletic performance were investigated in teams of soccer players while they were acclimatizing to an altitude of 3600 m above sea level. The study group consisted of players from Bolivia who normally lived at high altitude and players from Australia who normally lived at sea level. O2\mathrm{O}_{2} and CO2\mathrm{CO}_{2} concentrations in arterial blood were measured daily over a 12-day period. O2\mathrm{O}_{2} concentrations were measured as the percentage saturation of hemoglobin and CO2\mathrm{CO}_{2} concentrations were measured as partial pressure.

Figure for Question 1 — IB Biology HL

In the Australian players, the rate of ventilation increases initially with altitude.

Explain how the rate of ventilation is controlled in humans.

Question 1

[Maximum number: 3]

Fluids inside unicellular and multicellular organisms allow materials to be moved.

Outline how food is moved from the stomach to the large intestine.

No public sample questions are available for this syllabus point yet.

Exam points

  • Explain positive phototropism in shoots: under lateral light, auxin redistributes to the shaded side, where it promotes greater cell elongation so the shoot bends towards the light.

Question 1

[Maximum number: 1]

The image shows the response of a plant shoot to light exposure.

Before

Before

After

After

Naturwissenschaften. 96. 1339-1354, Springer Nature. Available at https://link.springer.com/article/10.1007/s00114-009-0604-z.]

What facilitates this response?

I. Auxin efflux carriers are located on one side of the cell.
II. Auxin promotes hydrogen ion secretion.
III. Cell walls become acidified and cellulose cross links are loosened.

A

I and II only

B

I and III only

C

II and III only

D

I, II and III

Question 1

[Maximum number: 1]

What is/are the effect(s) of auxin in plants?

I. Increasing the rate of cell elongation in stems
II. Changing the pattern of gene expression in shoot cells
III. Detecting the direction of light

A

I only

B

I and II only

C

II and III only

D

I, II and III

Exam points

  • Explain how PIN auxin efflux carriers move auxin between cells and how their asymmetric placement maintains gradients during tropic responses.

Question 1

[Maximum number: 1]

What correctly describes the action of auxin in phototropism?

A

Auxin efflux carriers actively transport auxin in and out of cells.

B

Auxin promotes hydrogen ion secretion into the cytoplasm.

C

Auxin efflux carriers are positioned in the plasma membrane on one side of the cell.

D

Auxin breaks beta-glucose links in the cell wall.

Exam points

  • Explain how auxin-driven gene expression and proton pumping acidify and loosen cell walls, allowing cell expansion and elongation; in shoots, greater shaded-side expansion supports bending.

Question 1

[Maximum number: 1]

Expansin is a plant protein that loosens connections between cellulose fibres in plant cell walls, allowing growth. In what location would expression of the expansin gene be expected to be increased?

A

On the shaded side of a shoot being exposed to light

B

On the light side of a shoot being exposed to light

C

On the shaded side of a leaf that is transpiring rapidly

D

On the light side of a leaf that is transpiring rapidly

No public sample questions are available for this syllabus point yet.

Exam points

  • Identify ethylene as the gaseous hormone that promotes fruit ripening, and explain how more ethylene released by ripening fruit creates positive feedback in nearby fruit.

Question 1

[Maximum number: 1]

Which chemical causes positive feedback to ensure rapid ripening of fruit?

A

Auxin

B

Cytokinin

C

Epinephrine

D

Ethylene

Question 1

[Maximum number: 3]

The diagram is a view of the human brain as seen from the left side.

Figure for Question 1 — IB Biology HL

Question (a)

(a)

On the diagram, label the cerebellum.

The graph shows the mean cerebellum volume from MRI scans in eight primate species arranged in order of increasing body mass.

Figure for Question (a) — IB Biology HL
[ 1 ]

Question (b)

(b)

Describe the use of fMRI to identify the role of the cerebellum.

[ 2 ]
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